The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, which are endogenous lipid-based retrograde neurotransmitters that bind to cannabinoid receptors, and cannabinoid receptor proteins that are expressed throughout the mammalian central nervous system (including the brain)
Phytocannabinoids – cannabinoids found in leaves, flowers, stems, and seeds collected from the Cannabis sativa plant.
Endogenous – cannabinoids made by the body: examples include N-arachidonoylethanolamine or anandamide (AE) or 2-arachidonoylglycerol (2-AG). AE and 2-AG activity can be manipulated by inhibiting their corresponding hydrolases FAAH or MAGL, preventing their degradation.
Purified naturally occurring cannabinoids purified from plant sources: examples include cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC),.
Synthetic cannabinoids synthesized in a laboratory: examples include CB1 agonists (CPP-55, ACPA), CB2 agonists (JWH-133, NMP7, AM1241), CB1/CB2 nonselective agonist (CP55940), ajulemic acid (AJA), nabilone, and dronabinol.
Conversely, CBD (cannabidiol) oil has been approved only in 15 states and, even then, is severely limited in most of those places. The restrictions in ...
Ella Turkington, 5, has intractable epilepsy and autism. Her parents Kim and Rob Turkington administers cannabidiol (CBD) oil in conjunction with her ...