The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, which are endogenous lipid-based retrograde neurotransmitters that bind to cannabinoid receptors, and cannabinoid receptor proteins that are expressed throughout the mammalian central nervous system (including the brain)
Phytocannabinoids – cannabinoids found in leaves, flowers, stems, and seeds collected from the Cannabis sativa plant.
Endogenous – cannabinoids made by the body: examples include N-arachidonoylethanolamine or anandamide (AE) or 2-arachidonoylglycerol (2-AG). AE and 2-AG activity can be manipulated by inhibiting their corresponding hydrolases FAAH or MAGL, preventing their degradation.
Purified naturally occurring cannabinoids purified from plant sources: examples include cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC),.
Synthetic cannabinoids synthesized in a laboratory: examples include CB1 agonists (CPP-55, ACPA), CB2 agonists (JWH-133, NMP7, AM1241), CB1/CB2 nonselective agonist (CP55940), ajulemic acid (AJA), nabilone, and dronabinol.
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