What is Cannabidiol

Cannabidiol... The Acronym =  (CBD)

At 2004 Cannabis Therapeutics Conference, Dr. Mechoulam, 
Professor at Hebrew University in Jerusalem, describes the role of 
Cannabinoids as anti-inflammatory for arthritis, 
as neuroprotectant for brain injury and as a possible treatment for PTSD
Scott Salisbury's take... Old videos have meaning too. 
I bought the CanChew Gum after I listened for a 2nd time. 

YouTube Video


the cbd store
CBD (cannabidiol) is a phytocannabinoid (or plant-derived cannabinoid) and one of many cannabinoids in hemp. This link shows the chemistry information about CBD: Source: MeSH
Record Name: Cannabidiol
URL: https://www.ncbi.nlm.nih.gov/mesh/68002185

Cannabidiol is a phytocannabinoid derived from Cannabis species, which is devoid of psychoactive activity, with analgesic, anti-inflammatory, antineoplastic and chemopreventive activities. Upon administration, cannabidiol (CBD) exerts its anti-proliferative, anti-angiogenic and pro-apoptotic activity through various mechanisms, which likely do not involve signaling by cannabinoid receptor 1 (CB1), CB2, or vanilloid receptor 1. CBD stimulates endoplasmic reticulum (ER) stress and inhibits AKT/mTOR signaling, thereby activating autophagy and promoting apoptosis. In addition, CBD enhances the generation of reactive oxygen species (ROS), which further enhances apoptosis. This agent also upregulates the expression of intercellular adhesion molecule 1 (ICAM-1) and tissue inhibitor of matrix metalloproteinases-1 (TIMP1) and decreases the expression of inhibitor of DNA binding 1 (ID-1). This inhibits cancer cell invasiveness and metastasis. CBD may also activate the transient receptor potential vanilloid type 2 (TRPV2), which may increase the uptake of various cytotoxic agents in cancer cells. The analgesic effect of CBD is mediated through the binding of this agent to and activation of CB1.

  • analgesic... Relief from pain 
  • antineoplastic... Acting to prevent, inhibit or halt the development of a neoplasm (a tumor). 
  • chemopreventive activities...  The use of a drug or compound to interfere with a disease process, for example, cancer chemopreventive agents — agents used to inhibit, delay, or reverse carcinogenesis.
  • Carinogenesis... the initiation of cancer formation anti-proliferative,
  • antiproliferative... used or tending to inhibit cell growth antiproliferative effects on tumor cells.
  • endoplasmic reticulum  a network of membranous tubules within the cytoplasm of a eukaryotic cell, continuous with the nuclear membrane. It usually has ribosomes attached and is involved in protein and lipid synthesis.
  • apoptosis... the death of cells which occurs as a normal and controlled part of an organism's growth or development.
  • endoplasmic reticulum (ER) The reactive oxygen species are the contributors of oxidative stress which lead to various diseases and disorders such as cardiovascular disease, cancer, aging

Current Assignee 
US Department of Health and Human Services (HHS)


Patent number US6630507B1

Cannabinoids as antioxidants and neuroprotectants

Abstract 

Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH3, and COCH3.
The Patent owned by Health and Human Services... 
Abstract... 



Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis


 




An interview with one of the corporate folks from hempMedsPX

If you have found yourself asking, “What is CBD?”, look no further. Cannabidiol (CBD) is one of at least 85 cannabinoids found in cannabis and industrial hemp. It is a major constituent of the plant, and represents up to 40% in its extracts. It is the decarboxylated form of CBDa (the ‘a’ means acid). Compared with THC, cannabidiol is considered to have a broader scope of medical applications than THC. Cannabidiol has displayed sedative effects in animal tests. Other research indicates that CBD increases alertness. CBD has been shown to reduce growth of aggressive human breast cancer cells in vitro, and to reduce their invasiveness [source].

CBD also promotes and supports the nutritional health of aging bodies. Source: US Government patent on Cannabinoids as Antioxidants and Neuroprotectants #6,630,507

ABOUT CBD

CBD is an acronym for cannabidiol, a prominent naturally-occurring cannabinoid component found in cannabis that comprises up to 40% of the plant. Cannabidiol is “a cannabinoid devoid of psychoactive effect. ” After THC (Δ9-tetrahydrocannabinol), CBD is by far the most studied natural cannabinoid. According to many researchers, CBD may be the single most important cannabinoid ever discovered.


Frequently Asked Questions

What is the endocannabinoid system? 
The endocannabinoid system (ECS) is one of science’s newest and most exciting discoveries. The ECS regulates relaxation, eating, sleeping, certain inflammation responses and even cognitive function. There are two types of cannabinoid receptors found throughout the body (CB1 and CB2), but they are most abundant in the brain and immune system respectively. In a nutshell, your ECS is responsible for making sure your entire body is working optimally—no small task!

Why would hemp (instead of marijuana) be grown for cannabidiol (CBD)? 
Industrial hemp is already rich in CBD and naturally low in THC, whereas most marijuana is just the opposite (high THC, low CBD). Our industrial hemp is considered Cannabis sativa L., although we have developed our own unique cultivars of this particular type of industrial hemp.

Through a combination of these unique cultivars, advanced plant genetics, and cutting-edge growing techniques, an exceptionally high percentage of CBD can be produced naturally and consistently in the hemp plant. When CBD-rich hemp oil is extracted from these hemp cultivars—which can be grown in dozens of countries and imported to the USA legally—it doesn’t make legal or practical sense to obtain CBD from marijuana.

Will CBD help me with my illness? 
Due to FDA regulations, we cannot make claims about whether or not CBD can help with specific ailments. We do, however, suggest that you conduct your own research.

Will CBD help me if I’m healthy? 
Each individual is unique and has different wellness goals they are interested in addressing through the consumption and application of our products. Although some of our founders are medical professionals, we cannot make medical claims about the benefits of our products. The products sold from this website are considered nutritional supplements or personal care products, according to FDA guidelines.

We encourage you to discuss CBD with your physician or healthcare practitioner if you have any specific health-related questions or concerns. There are also many independent, peer-reviewed studies about CBD available on the internet.

Are CBD and THC the same thing? 
No, they are different compounds. CBD and THC are both cannabinoids, but THC is the cannabinoid that gets you “high” or “stoned.” CBD is non-psychoactive, meaning it won’t get you “high.”

Can I get high from CBD products? 
Our CBD comes from carefully-cultivated hemp plants—not marijuana—which is why it is legal for us to import and use this CBD-rich oil. Our parent company spent years developing special cultivars of the hemp that produce naturally high levels of CBD and only trace amounts of THC, the psychoactive compound that gives marijuana users the “high” feeling. In comparison to hemp, most recreational cannabis plants have between 5% to over 20% THC.

Can you make any claims about what CBD can do? 
No. Our CBD-rich hemp oil products can fall into two different categories depending on how they are marketed and sold: they can be considered a food or a nutritional supplement. Our CBD is a natural constituent of industrial hemp oil.

The CBD found in our CBD gum and RSHO Oil is extracted via an advanced steam distillation process from high CBD industrial hemp.

Some Potential Medical Benefits of CBD:

CBD benefits

Image courtesy of SC Laboratories

  • CBD has been found to be anti-spasmodic and antiepileptic, which could be beneficial for those who suffer from epilepsy, Dravet’s Syndrome, Multiple Sclerosis (MS), ALS, among others.
  • At high doses (more than several hundred mg) CBD can be a sedative, and also helps insomniacs stay asleep longer. In low doses, CBD has been found to be alerting.
  • CBD is effective as an anti-inflammatory, anti-anxiety (anxiolytic) and relieving for nausea (anti-emetic)
  • CBD is a powerful pain reliever (analgesic)
  • CBD has been shown to inhibit cancer cell growth (anti-carcinogenic).
  • CBD helps the immune system function more efficiently.
  • CBD is a neuroprotectant and a powerful antioxidant. It has applications in treatment for Alzheimer’s, Parkinsons, cerebral ischemia as well as brain and nerve damage from strokes.
  • CBD is an anti-psychotic and recent research has indicated it is effective in treatment of schizophrenia.
  • CBD could be effective in easing symptoms of a wide range of difficult-to-control conditions, including: rheumatoid arthritis, diabetes, alcoholism, PTSD, epilepsy, MS, antibiotic-resistant infections and neurological disorders, to name a few.
  • CBD as been found to be effective in treating gastrointestinal disorders like Irritable Bowel Disorder (IBD), Crohn’s Disease, or Ulcertative Colitis.
  • CBD has shown some inclination to being beneficial for those with autism

   CBD Health and Wellness

 We donate 10% of our profits back to Mary Lynn's...  Cannabis as Medicine
 Mary Lynn did not reach out to help me. She and I have never met nor have we ever spoke to each other, rather she took the time to learn and post that which she learned. It is because of Mary Lynn I started this store and have my health back. Start of story Line Sept of 2012. 


YES that which I write about the US of A Health and Human Resources owns the 
Patent on! REALLY!!!

Mary Lynn Mathre  
The endocannabinoid system (ECS) is one of science’s newest and most exciting discoveries. The ECS regulates relaxation, eating, sleeping, certain inflammation responses and even cognitive function. There are two types of cannabinoid receptors found throughout the body (CB1 and CB2), but they are most abundant in the brain and immune system respectively. In a nutshell, your ECS is responsible for making sure your entire body is working optimally—no small task!

Mary Lynn Mathre


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